Treeforts - Vacation Rentals in South Main

Beautiful Contemporary Apt in TX Med Centre, NRG Stadium From US $242
         

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10.0 (1 Review)
Apartment
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  • Pool
Welcoming 3-bedroom townhome in Heart of Houston From US $503
         

9.4 (6 Reviews)
House
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3 Bedrooms, Spacious Central Condo w Pool From US $382
         

8.0 (1 Review)
Apartment
  • Air Conditioner
  • Parking
  • TV
Sophisticated Haus- Houston Near NRG Stadium From US $194
         

2.0 (3 Reviews)
Apartment
  • Air Conditioner
  • Parking
  • Pool
Luxury studio with AC, WiFi in wonderful Houston From US $121
         

2.0 (2 Reviews)
Apartment
  • Air Conditioner
  • Security/Safety
  • Bedding/Linens

Luxury Places to Stay in South Main

Over 197+ Luxury Places to Stay in or Near South Main
3BR Houston home near NRG World Cup & Med Center From US $385
         

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Charming 1-bedroom house in delightful Houston with WiFi From US $272
         

8.0 (1 Review)
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The Houston Reston From US $252
         

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10.0 (6 Reviews)
Villa
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Spacious 3BR, 2BA Condo near Medcenter & NRG From US $217
         

6.6 (44 Reviews)
Apartment
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Sterling Inn and Suites at Reliant and Medical Center Houston From US $167
         

6.3 (421 Reviews)
Hotel
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  • Wheelchair Accessible

Top-Rated Vacation Rentals with a Pool in South Main

Over 125+ Top-Rated Vacation Rentals with a Pool in or Near South Main
Medtropolis Medical Center/Downtown/Galleria/NRG From US $106
         

10.0 (1 Review)
Apartment
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  • Pool
3 Bedrooms Spacious Central Condo w Pool From US $136
         

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9.5 (2 Reviews)
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The Reside Fully Furnished Condos - Medical Stays Welcome From US $140
         

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8.8 (243 Reviews)
Apartment
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  • Pet Friendly
Comfort Suites Houston near Medical Center- NRG Stadium From US $120
         

Close 411 From US $109
         

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7.6 (5 Reviews)
Apartment
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  • Pet Friendly
Quality Inn & Suites NRG Park - Medical Center From US $106
         

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7.0 (618 Reviews)
Hotel
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  • Pet Friendly

Pet-Friendly Vacation Rentals in South Main

Over 46+ Pet-Friendly Vacation Rentals in or Near South Main
Cozy Modern Apartment with patio and pool. From US $86
         

1.0 (1 Review)
Apartment
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  • Pet Friendly
Tx Home Group - Medical Center From US $190
         

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9.0 (2 Reviews)
Apartment
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  • Pet Friendly
Regards At Med Center 372 I Spacious 1 Bed 1 Bath From US $110
         

Sunny Days From US $150
         

5.0 (1 Review)
House
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  • Pet Friendly
  • Pool
NRG/MED CENTER MINS FROM EVERYTHING!! THE PERFECT GETAWAY!!! From US $170
         

4.5 (2 Reviews)
House
  • Air Conditioner
  • Pet Friendly
  • Child Friendly
Regards At Med Center 162 I Comfy 2 Bed 2 Bath From US $126
         

2.0 (1 Review)
Apartment
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  • Pet Friendly
Home Away From Home-2 Bedroom Apartment From US $115
         

2.0 (1 Review)
Apartment
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  • Pet Friendly
  • Pool
Tx Home Group - Medical Center From US $291
         

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  • Pet Friendly

Large Vacation Homes & Villas in South Main

Over 8+ Large Vacation Homes & Villas in or Near South Main
Tx Home Group From US $108
         

New
House
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  • Pet Friendly
  • Pool
Welcoming 3-bedroom townhome in Heart of Houston From US $249
         

8.4 (7 Reviews)
House
  • Security/Safety
  • Bedding/Linens
  • Fireplace/Heating
Sleeps Groups | Houston NRG Stadium | Private 2BR From US $350
         

4.5 (2 Reviews)
Apartment
  • Air Conditioner
  • Pool
  • Child Friendly
Adorable three bed two bath Condo by Medical Center/Rodeo/NRG From US $87
         

Wheelchair Accessible Vacation Homes in South Main

Over 33+ Wheelchair Accessible Vacation Homes in or Near South Main
Spacious Loft Apartment Med Center, NRG Stadium From US $77
         

1.0 (1 Review)
Apartment
  • Air Conditioner
  • Parking
  • Pool
Comfort Suites Houston near Medical Center- NRG Stadium From US $139
         

Your Emerald Luxury Escape-King Suite/MED/NRG/DTWN From US $155
         

10.0 (2 Reviews)
Apartment
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The Luxxe Suite (NRG Stadium + Med Center) From US $178
         

9.0 (2 Reviews)
Apartment
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  • Parking
  • Pool
Walk to NRG|Near Med center| Museum|Rice U|Zoo From US $135
         

8.8 (10 Reviews)
Condo
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  • Parking
  • Pool
Lovely 3 BR, 2BA condo w/grill. Near Medcenter and NRG From US $140
         

4.1 (7 Reviews)
Condo
  • Air Conditioner
  • Pool
  • Wheelchair Accessible

South Main Vacation Rentals and Airbnb Places to Stay Under $200

Over 132+ South Main Vacation Rentals and Airbnb Places to Stay Under $200
Lovely Med center 3BR 2BA condo with free parking From US $135
         

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1.0 (12 Reviews)
House
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Candlewood Suites Houston Medical Center by IHG From US $112
         

7.4 (867 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Designated Smoking Area
NRG Walking Distance/Medical center/Museum From US $120
         

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Condo
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  • Child Friendly
Relaxation at The Med Center From US $78
         

Private Room Near TMC From US $74
         

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Apartment
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Instantly Bookable Vacation Homes in South Main

Over 83+ Instantly Bookable Vacation Homes in or Near South Main
The Cure Lounge "Your away from home Antidote" From US $138
         

9.0 (28 Reviews)
Condo
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  • Parking
  • Pool
King Size Beauty. NRG/Med Cntr From US $240
         

8.0 (8 Reviews)
Apartment
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  • Pool
  • Security/Safety
First Floor Med Center NRG Walkable-Metro Rail From US $111
         

8.0 (2 Reviews)
Apartment
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  • Parking
  • Pool
Cozy condo near NRG stadium and Texas Medical Center From US $100
         

8.0 (2 Reviews)
Condo
  • Air Conditioner
  • Pool
  • Security/Safety
Near NRG Park Pool Access Sleeps 2 From US $100
         

7.0 (2 Reviews)
Apartment
  • Air Conditioner
  • Parking
  • Pool
Comfy 1Bdr Apt MedCenter Mins from NRG & Downtown From US $119
         

5.0 (2 Reviews)
Apartment
  • Air Conditioner
  • Pool
  • Bedding/Linens
Cozy Med-Center Retreat-mins from NRG Downtown From US $135
         

5.0 (1 Review)
Apartment
  • Air Conditioner
  • Pool
  • Child Friendly

About South Main Vacation Rentals

With more than 206 South Main vacation rentals, we can help you find a place to stay. These rentals, including vacation rentals, Treeforts and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at a rental property in South Main.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With Treeforts South Main, you have the flexibility of comparing different options of various deals with a single click. Looking for a rental by owner with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner, and other popular Airbnb-style properties in South Main. Places to stay near South Main are 447.57 ft² on average, with prices averaging US $164 a night.

Treeforts makes it easy and safe to find and compare vacation rentals in South Main with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

Top Rental Accommodation Types in South Main

Type Count
Holiday Apartments 134
Vacation Homes 33
Hotels 10
B&B 1
Villas 1

Use these Quick Filters to Find a Vacation Rental in South Main

Pro Tip: Treeforts makes it easy to compare the best listings on Treeforts homes from online vacation rental OTAs, including Booking.com and more. Use the Advanced Filter feature at the top to easily flip between Treeforts homes, vacation rentals, bed and breakfasts, private Airbnb-style rentals availability, eco-friendly properties, property type, cancellation policies, prices, and several different options. All these make it easier to find the perfect accommodation for your next vacation in South Main.

Weather in South Main

View the weather forecast for South Main before booking your South Main Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Complexes around South Main, TX


South Main Vacation Rental Frequently Asked Questions

What are the top vacation rentals in South Main?
How many vacation rentals are available in South Main?

Currently, the total number of properties listed in 2026 is over 206 in the South Main area, and still counting. By aggregating listings from multiple websites, offers an immense amount of choice of the best properties in South Main.